Pharmaceutical Particle Engineering via Spray Drying
نویسندگان
چکیده
منابع مشابه
Simultaneous Polymerization and Polypeptide Particle Production via Reactive Spray-Drying
A method for producing polypeptide particles via in situ polymerization of N-carboxyanhydrides during spray-drying has been developed. This method was enabled by the development of a fast and robust synthetic pathway to polypeptides using 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU) as an initiator for the ring-opening polymerization of N-carboxyanhydrides. The polymerizations finished within 5 s a...
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Spray drying is presently one of the most interesting technologies in the pharmaceutical industry. The process shows a remarkable capability in manipulating powder/particle attributes such as size, morphology, density and level of residual solvents. This flexibility led to its application in a variety of powder formulations and advanced solid forms: from very fine powders for inhalation to larg...
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A mathematical model for the evaporation of a single droplet, subjected to convective drying in a spray dryer was developed to study the transient phenomena of particle formation. During the constant-rate drying period, the governing equations and boundary conditions were transformed into a form containing Peclet number, Pe, as the main controlling parameter. A numerical solution was developed ...
متن کاملSpray-drying Cellulose Nanofibrils: Effect of Drying Process Parameters on Particle Morphology and Size Distribution
Spray-drying was chosen as an appropriately scalable manufacturing method to dry cellulose nanofibril (CNF) suspensions. Spray-drying of two different types of CNF suspensions—nanofibrillated cellulose (NFC) and cellulose nanocrystals (CNC)—was carried out using a laboratory-scale spray dryer. Effects of three spray-drying process parameters on particle morphology and particle size distribution...
متن کاملEffects of Spray Drying and Spray Chilling on Ibuprofen Dissolution
The formulation of hydrophobic drugs for oral drug delivery is challenging due to poor solubility, poor dissolution and poor wetting of these drugs. Consequently, the aim of this study was to improve the dissolution of a model poorly water soluble drug, ibuprofen. Microparticles containing ibuprofen were produced by spray drying and spray chilling technology in the absence/presence of a ...
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ژورنال
عنوان ژورنال: Pharmaceutical Research
سال: 2007
ISSN: 0724-8741,1573-904X
DOI: 10.1007/s11095-007-9475-1